Table 1.
Genes present in the red cell membrane and routinely tested in pharmacogenomics.
| Gene | Red cell membrane confidence threshold* | Pharmacogenomics platform |
|
|---|---|---|---|
| DMET | PharmacoScan | ||
| ABCC1 | High | Yes | Yes |
| ABCC4 | High | Yes | Yes |
| ABCC5 | High | Yes | Yes |
| ABCG2 | High | Yes | Yes |
| SLC16A1 | High | Yes | Yes |
| SLC19A1 | Medium | Yes | Yes |
| SLC29A1 | High | Yes | Yes |
| CYP4F3 | Medium | Yes | Yes |
| CFTR | High | No | Yes |
| FLOT1 | High | No | Yes |
| ATP7A | High | Yes | Yes |
| EPHX1 | High | Yes | Yes |
*
High = identified in at least 2 mass spectrometry-based studies, an established blood group, or a CD marker for red cells; Medium = identified in only 1 mass spectrometry-based study [34].