Table 3.
Protein characteristics of the 12 genes.
| Gene | Protein | Length (amino acids) | Topology* |
Transmembrane segments | |
|---|---|---|---|---|---|
| Amino-terminal | Carboxy-terminal | ||||
| ABCC1 | Multidrug resistance-associated protein 1 (MRP1) | 1531 | Extracellular | Cytoplasm | 17 |
| ABCC4 | Multidrug resistance-associated protein 4 (MRP4) | 1325 | Cytoplasm | Cytoplasm | 12 |
| ABCC5 | Multidrug resistance-associated protein 5 (MRP5) | 1437 | Cytoplasm | Cytoplasm | 12 |
| ABCG2 | ATP-binding cassette sub-family G member 2 (ABCG2) | 655 | Cytoplasm | Cytoplasm | 6 |
| SLC16A1 | Monocarboxylate transporter 1 (MCT1) | 500 | Cytoplasm | Cytoplasm | 12 |
| SLC19A1 | Folate transporter 1 (RFC1) | 591 | Cytoplasm | Cytoplasm | 12 |
| SLC29A1 | Equilibrative nucleoside transporter 1 (ENT1) | 498 | Cytoplasm | Extracellular | 11 |
| CYP4F3 | Docosahexaenoic acid omega-hydroxylase (LTB4H) | 520 | Extracellular | Cytoplasm | 1 |
| CFTR | Cystic fibrosis transmembrane conductance regulator (CFTR) | 1480 | Cytoplasm | Cytoplasm | 12 |
| FLOT1 | Flotillin-1 (FLOT1) | 427 | Cytoplasm | Cytoplasm | 0 |
| ATP7A | Copper-transporting ATPase 1 (MNK) | 1500 | Cytoplasm | Cytoplasm | 8 |
| EPHX1 | Epoxide hydrolase 1 (EPHX1) | 455 | Cytoplasm | Extracellular | 1 |
*
Predicted or experimentally proven location of the amino- or carboxy-terminal protein ends at the cytoplasmic or extracellular side of the plasma membrane.