Table 4.

Common substrate drugs of the 12 genes.

Gene	Substrate drugs
ABCC1	Doxorubicin, methotrexate
ABCC4	Antivirals: acyclovir, ritonavir, adefovir, tenofovir; Diuretics: furosemide, hydrochlorothiazide; Cephalosporins: ceftizoxime, cefazolin; Cytotoxic drugs: methotrexate, 6-mercaptopurine, 6-thioguanine, topotecan; olmesartan, para-methoxy-N-ethylamphetamine. renal excretion of a wide variety of antiviral, cytostatic, antibiotic and cardiovascular drugs
ABCC5	Methotrexate, 6-thioguanine (anticancer drug), PMEA (anti-HIV drug), 5-fluorouracil, rosuvastatin, atorvastatin, kainic acid, domoic acid, ZJ43
ABCG2	Anthracyclines, daunorubicin, doxorubicin, topotecan, SN-38, irinotecan, methotrexate, imatinib, irinotecan, Mitoxantrone, nucleoside analogs, prazosin, pantoprazole, statins, topotecan, rosuvastatin, teriflunomide, chlorothiazide
SLC16A1	3-bromopyruvate (3-BrPA), a cancer drug candidate that inhibits glycolysis
SLC19A1	5-methyl-tetrahydrofolate, methotrexate
SLC29A1	Cladribine, cytarabine (for AML, ALL etc), fludarabine, gemcitabine capecitabine fialuridine, ribavirin
CYP4F3	Metabolize numerous drug substrates
CFTR	Ivacaftor
FLOT1	Carbamazepine
ATP7A	Cisplatin, oxaliplatin, carboplatin (overexpression causes sequestration of the drugs into intracellular vesicles)
EPHX1	Carbamazepine