Table 2. Primary and Secondary Outcomes.
| Prone positioning (n = 205) |
Control (n = 195) |
Difference (95% CI) | Effect (95% CI) | P value | |
|---|---|---|---|---|---|
| Primary outcome | |||||
| Endotracheal intubation within 30 d of randomization, No. (%) | 70 (34) | 79 (41) | Absolute, −6.37 (−15.83 to 3.10)a | HR, 0.81 (0.59 to 1.12)b | .20 |
| RR, 0.87 (0.71 to 1.07)c | .19 | ||||
| Per-protocol analysis, No./total No. (%) | 62/184 (34) | 57/157 (36) | Absolute, −2.61 (−12.77 to 7.55)a | HR, 0.89 (0.62 to 1.28)b | .54 |
| Secondary outcomes | |||||
| Mortality at 60 d, No. (%) | 46 (22) | 46 (24) | Absolute, −1.15 (−9.40 to 7.10)a | HR, 0.93 (0.62 to 1.40)b | .72 |
| Days free from invasive mechanical ventilation or noninvasive ventilation at 30 d, mean (SD) | 21.4 (12.7) | 19.4 (13.2) | Mean, 2.04 (−0.50 to 4.59)d | .12 | |
| Days free from invasive mechanical ventilation at 30 d, mean (SD) | 21.6 (12.4) | 19.6 (13.1) | Mean, 2.03 (−0.47 to 4.54)d | .11 | |
| ICU-free days at 60 d, mean (SD) | 38.6 (23.6) | 34.5 (24.6) | Mean, 4.07 (−0.67 to 8.81)d | .09 | |
| Hospital-free days at 60 d, mean (SD) | 34.4 (22.9) | 30.8 (23.5) | Mean, 3.52 (−1.05 to 8.08)d | .13 | |
Abbreviations: HR, hazard ratio; ICU, intensive care unit; RR, relative risk.
a
Expressed as percentages.
b
Generated using an unadjusted Cox proportional hazards regression model for the primary analysis.
c
Generated using the χ2 test.
d
Generated using an unadjusted linear regression analysis.