Fig. 4.

Cortical injury inversely correlates with flurothyl seizure susceptibility after neonatal hypoxia-ischemia in a sex-specific manner. Correlation of cortical injury with latency (in seconds) to stage 3 seizure (A) and stage 5 seizure (B) is shown for the whole group, and in females (A₁, B₁), and males (A₂, B₂). When stratified by sex, cortical injury correlates with latency to stage 5 seizure in male pups only (B₁ vs. B₂). Nonparametric Spearman Rho correlation statistics were used for data analysis. C Representative cresyl violet-stained cortical samples for injury scores of 0–3.