Table 4.
Multivariable Cox regression analysis of OS and DFS
| DFS |
CSS |
OS |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| n (%)* | relative risk (95% Cl)† | p value | n (%)** | relative risk (95% Cl)† | p value | n (%)*** | relative risk (95% Cl)† | p value | |
| CXCR1 +860, n (%) | 0.008 | 0.001 | 0.001 | ||||||
| CC§ | 84 (84) | 1 | 84 (84) | 1 | 77 (83.7) | 1 | |||
| GC | 16 (16) | 3.679 (1.399–9.672) | 16 (16) | 4.957 (1.922–12.781) | 15 (16.3) | 3.761 (1.727–8.190) | |||
| Hb, n (%) | 0.003 | 0.012 | − | ||||||
| ≤12 | 38 (38) | 2.805 (1.407–5.592) | 38 (38) | 2.392 (1.216–4.705) | − | − | |||
| >12 | 62 (62) | 1 | 62 (62) | 1 | − | − | |||
| Adjuvant therapy, n (%) | 0.015 | 0.032 | − | ||||||
| No | 63 (63) | 1 | 63 (63) | 1 | − | − | |||
| Yes | 37 (37) | 2.359 (1.180–4.715) | 37 (37) | 2.072 (1.067–4.024) | − | − | |||
| L, n (%) | − | − | 0.008 | ||||||
| L0 | − | − | − | − | 75 (81.5) | 1 | |||
| L1 | − | − | − | − | 17 (18.5) | 2.743 (1.301–5.783) | |||
| CCI, n (%) | − | − | 0.017 | ||||||
| ≤40 | − | − | − | − | 47 (51.1) | 1 | |||
| >40 | − | − | − | − | 45 | 2.311 (1.158–4.613) | |||
Only significant variables and outcomes are shown. Significant parameters in univariate analysis were included in the respective multivariate analysis for DFS, CSS, and OS. For DFS, hemoglobin (≤12/>12 g/dL), intraoperative blood and FFP transfusions, tumor grading (G1-2/G3-4), UlCC (I-II/III-IV), N category (pN0/pN1), CCI (≤40/>40), adjuvant therapy, and the CXCR1 +860C>G SNP were included. For CSS, EBD, hemoglobin (≤12/>12 g/dL), intraoperative blood and FFP transfusions, tumor grading (G1-2/G3-4), UICC (I-II/III-IV), N category (pN0/pN1), ICU time (≤1/>1 day), CCI (≤40/>40), adjuvant therapy, and the CXCR1 +860C>G SNP were included. For OS, preoperative cholangitis, hemoglobin (≤12/>12 g/dL), intraoperative blood and FFP transfusions, lymphovascular invasion, tumor grading (G1-2/G3-4), UICC (I-II/III-IV), tumor stage (pT1-2/pT3-4), N category (pN0/pN1), ICU time (≤1/>1 day), CCI (≤40/>40), tumor recurrence, and the CXCR1 +860C>G SNP were included.
100 patients with complete data were included in the model.
100 patients with complete data were included in the model.
92 patients with complete data were included in the model.
Determined as the favorable allele.