Table 3.
Predictors of ESKD at second kidney biopsy
| Variable | Univariable analysis | Multivariable analysis | ||||
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Age at second biopsy | 1.01 | 0.94 to 1.10 | 0.33 | – | – | – |
| Male gender | 2.21 | 0.74 to 6.64 | 0.16 | – | – | – |
| Time elapsed between first and second biopsy | 1.05 | 0.91 to 1.13 | 0.22 | – | – | – |
| Use of IS at time of second biopsy | 0.82 | 0.28 to 2.33 | 0.72 | – | – | – |
| Serum creatinine mg/dL | 1.61 | 1.34 to 1.91 | <0.001 | 1.20 | 0.79 to 1.85 | 0.39 |
| eGFR mL/min/1.73 m2 | 0.97 | 0.95 to 0.98 | 0.001 | – | – | – |
| Proteinuria g/day | 1.23 | 1.11 to 1.36 | <0.001 | 1.22 | 1.04 to 1.42 | 0.013 |
| Arterial hypertension | 11.71 | 1.6 to 87.1 | 0.016 | 4.9 | 0.6 to 40.4 | 0.14 |
| Proliferative Class ISN/RPS 2003 | 7.41 | 0.99 to 54.9 | 0.050 | – | – | – |
| AI | 1.14 | 0.99 to 1.32 | 0.059 | 1.20 | 1.03 to 1.41 | 0.022 |
| CI | 1.32 | 1.02 to 1.51 | 0.030 | 1.41 | 1.09 to 1.82 | 0.008 |
Variables included in the model: Serum Creatinine, hypertension, proteinuria, AI, CI.
Significant variables at multivariable analysis are highlighted in bold
AI, activity index; CI, chronicity index; eGFR, estimated glomerular filtration rate; ESKD, end-stage kidney disease; IS, immunosuppressants; ISN/RPS, International Society of Nephrology/Renal Pathology Society.