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. 2022 Apr 25;65(9):6513–6540. doi: 10.1021/acs.jmedchem.1c01756

Figure 4.

Figure 4

Crystal structure of the ERK5–34b complex determined at 2.75 Å (PDB: 7PUS). (a) Hydrogen-bonding interactions of the pyrrole NH and amide carbonyl to the hinge region of ERK5. (b) Interaction of the pyrazole with the side chains of I61, E146, and the backbone of M140.