Table 2. ERK5 Inhibitory Activity and In Vitro ADME Data for 32i–k and 33b–f.

^aERK5 IC₅₀’s determined using an IMAP FP progressive binding system kit (Molecular Devices #R8127).

^bIC₅₀ determined by phospho-ERK5 Western blot densitometry in HeLa cells (1 h incubation with compounds).

^cμL/min/mg protein.

^dP_app 10^–6 cm·s^–1.