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Fig. 2. The synthesis of D8-M3-PEG-HA polymers and the preparation of D8-M3-HA-ZIF8@BTZ NPs. (A and B) Synthesis route, 1H-NMR spectrum of D8-M3-PEG-HA; (C) TEM images of ZIF8, ZIF8@BTZ, HA-ZIF8@BTZ, D8-M3-HA-ZIF8@BTZ NPs; (D) FT-IR spectrum of D8-M3-PEG-HA; (E and F) DLS and zeta potential analysis of D8-M3-HA-ZIF8@BTZ NPs and other NPs (n = 3).