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. 2022 Apr 15;13(5):827–832. doi: 10.1021/acsmedchemlett.2c00064

Table 1. SAR of Phenyl Derivatives Containing the KU-177 Biaryl Side Chain.

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entry R1 R2 R3 R4 R5 IC50
7a H H H H H >10 μM
7b H H OH H H >10 μM
7c H H OMe H H >10 μM
7d H H Cl H H 6.03 ± 1.9 μM
7e H H F H H 6.32 ± 3.1 μM
7f H H COOMe H H >10 μM
7g H H CN H H 8.57 ± 0.3 μM
7h H H CF3 H H 4.83 ± 0.9 μM
7i H H NO2 H H 4.04 ± 0.5 μM
7j OMe H OMe H H 9.53 ± 0.3 μM
7k Cl H Cl H H >10 μM
7l H Cl Cl H H >10 μM
7m Cl H H H H >10 μM
7n H OMe H OMe H >10 μM
7o H Cl H H H >10 μM
7p H COOMe H H H >10 μM
7q H NO2 H H H >10 μM