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. 2022 Apr 29;13(5):848–854. doi: 10.1021/acsmedchemlett.2c00120

Table 4. Comparison of the Pharmacokinetic Profiles of S2157 and S1427a.

parameter S2157 S1427 (10a)
AUC0–∞ (μM·h) 0.98 5.09
Cmax (μM) 0.96 3.03
Tmax (h) 0.25 0.50
T1/2 (h) 0.95 3.90
a

Compounds were administered via a single intraperitoneal injection at a dosage of 10 mg/5 mL per kilogram (n = 3) to an ICR-strain mouse (eight weeks old, male).