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. 2022 May 16;13:206. doi: 10.1186/s13287-022-02884-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Magnetic resonance imaging (MRI) detection of MIRB-labeled integrin α10-MSCs in a cartilage defect. A focal cartilage defect was created surgically and MIRB-labeled integrin α10-MSCs were injected 7 days later. 3D-FLASH MRI coronal (A) and 3D-FISP MRI sagittal (B) views of the knee of rabbit #1 and #6 at baseline (after surgery but before injection), 12 h (12h), 4 days (4d) and 7d after integrin α10-MSC injection. The chondral defect is indicated (dotted lined box) and inserts show the magnification of the cartilage defect area. Labeled integrin α10-MSCs aggregating in the defect are detected as hypointense black material. MIRB Molday ion conjugated with Rhodamine B