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. 2022 May 16;13:206. doi: 10.1186/s13287-022-02884-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Magnetic resonance imaging (MRI) signal intensity (SI) in the cartilage defects after homing of labeled integrin α10-MSCs. All images of the same rabbit were aligned. A 3D region of interest (ROI) was marked in the area of the cartilage defect (indicated in Fig. 6) and SI in the ROI was automatically calculated. The graph shows the % drop in SI from baseline. An SI drop indicates accumulation of labeled α10-MSCs in the defect. The SI drop was statistically significant on day 4 (p = 0.036) relative to baseline. Note that rabbit #3 was removed from the study because of unintentional peri-articular injection of labeled α10-MSCs