Table 1.

Visual grading of integrin α10-MSC distribution on magnetic resonance images

	0 h	12 h	24 h	2 days	4 days	7 days	10 days
Rabbit 1
Cartilage Defect		+++			++	+
Surrounding Cartilage		0			0	0
Synovial Membrane		+++			+	+
Infrapatellar Fat Pad		+			0	0
Rabbit 2
Cartilage Defect			+		+		0
Surrounding Cartilage			0		0		0
Synovial Membrane			++		+		+
Infrapatellar Fat Pad			0		0		0
Rabbit 4
Cartilage Defect	0			+	+		0
Surrounding Cartilage	0			0	0		0
Synovial Membrane	++			++	+		0
Infrapatellar Fat Pad	0			0	0		0
Rabbit 5
Cartilage Defect	+		+		+
Surrounding Cartilage	+		0		0
Synovial Membrane	++		+		+
Infrapatellar Fat Pad	+		0		0
Rabbit 6
Cartilage Defect		++		++	+	+
Surrounding Cartilage		0		0	0	0
Synovial Membrane		++		+	+	+
Infrapatellar Fat Pad		+		+	0	0

Distribution of labeled mesenchymal stem cells selected for a high expression of integrin α10β1 (integrin α10-MSCs) after intra-articular injection in the knee of 6 rabbits with a surgically created cartilage defect. The distribution is determined by visual grading of magnetic resonance images. Distribution and cell concentration was graded subjectively as 0 = none; +  = mild; ++  = moderate; +++  = marked; gray box = rabbit not scanned at that timepoint. Rabbit #3 was removed from the study because of unintentional peri-articular injection of labeled α10-MSCs