Table 4.
Univariate and multivariable Cox proportional-hazards regression analysis on overall survival
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| Variables | HR (95% CI) | p-Value | HR (95% CI) | p-Value |
| Age (mean ± SD) | 1.031 (1.008–1.053) | 8.67 × 10−3* | 1.027 (1.001–1.055) | 4.26 × 10−2* |
| Gender (male/female) | 0.782 (0.489–1.252) | 3.05 × 10−1 | NA | NA |
| Alcohol (yes/no) | 0.864 (0.588–1.269) | 4.55 × 10−1 | NA | NA |
| Tobacco (yes/no) | 0.749 (0.508–1.105) | 1.44 × 10−1 | NA | NA |
| Pathologic N (N0/N1/N2/N3) | 1.438 (1.181–1.751) | 2.51 × 10−4* | 1.025 (0.751–1.400) | 8.75 × 10−1 |
| Pathologic T (T1/T2/T3/T4) | 1.187 (0.910–1.549) | 2.05 × 10−1 | NA | NA |
| Pathologic stage (I/II/III/IV) | 1.994 (1.398–2.846) | 1.12 × 10−4* | 1.904 (1.062–3.412) | 4.58 × 10−2* |
| Arrhythmia (yes/no) | 1.120 (0.727–1.725) | 6.07 × 10−1 | NA | NA |
| Pneumonia (yes/no) | 1.425 (0.719–2.823) | 3.07 × 10−1 | NA | NA |
| Anastomotic leak (yes/no) | 1.299 (0.603–2.798) | 5.03 × 10−1 | NA | NA |
| Adjuvant therapy (yes/no) | 2.264 (1.313–3.904) | 2.53 × 10−3* | 1.655 (0.982–2.787) | 5.05 × 10−2 |
| RS model status (high/low) | 2.456 (1.651–3.654) | 4.71 × 10−6* | 2.205 (1.415–3.435) | 4.73 × 10−4* |
*Statistically significant; RS risk score, HR hazard ratio, CI confidence interval, NA not analyzed