Table 1.
Top five canonical pathways upregulated in both B6 [WT to MUT] and NSG [WT to MUT] mice
| Pathway | B6 WT to MUT | NSG WT to MUT |
|---|---|---|
| p-value | p-value | |
| B-H value | B-H value | |
| Z-score | Z-score | |
| Neuroinflammation signaling | 4.97E-12 | 2.15E-06 |
| 5.1E-10 | 7.33E-05 | |
| 6.303 | 3.638 | |
|
| ||
| Production of nitric oxide | 3.17E-11 | 3.08E-06 |
| 2.32E-09 | 9.59E-05 | |
| 5.06 | 3.464 | |
|
| ||
| Role of NFAT in regulation of the immune response | 2.26E-08 | 1.21E-05 |
| 4.14E-07 | 2.26E-04 | |
| 5 | 3.464 | |
|
| ||
| Dendritic cell maturation | 4.31E-14 | 1.64E-09 |
| 7.36E-12 | 1.02E-05 | |
| 4.938 | 2.887 | |
|
| ||
| TREM1 signaling | 1.23E-10 | 3.52E-06 |
| 5.73E-09 | 9.59E-05 | |
| 4.707 | 3 | |