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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Curr Opin Genet Dev. 2021 Sep 1;71:163–170. doi: 10.1016/j.gde.2021.08.002

Figure 3. BIR is involved in repairing DSBs associated with replication stress.

Figure 3.

(A). Activation of BIR is differently regulated at DSBs generated by endonucleases (replication-independent) and replication-associated DSBs. REC is only required for BIR activation at replication-independent DSBs.

(B). Replication stress induced by various causes activation of BIR not only at single-ended DSBs (seDSBs) but also at double-ended DSBs (deDSBs) generated after fork converging.