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. Author manuscript; available in PMC: 2022 May 16.
Published in final edited form as: J Hypertens. 2020 Mar;38(3):456–466. doi: 10.1097/HJH.0000000000002295

Figure 1. Impact of CHGA on glomerular function.

Figure 1.

(A) Time course on the effect of CHGA accumulation on eGFR. WT and KO mice (N=12 each of the 4 groups), 8 weeks of age, were subjected to sham or Npx surgery and their weekly eGFR was estimated by measuring the plasma creatinine levels. The data was analyzed by repeated measure ANOVA using linear mixed model and showed significant differences in creatinine measurements between the two mouse strains subjected to Npx. (B) Elevated CHGA in the CKD mouse model. The WT-Npx mice showed 1.4-fold elevated plasma CHGA level as compared to sham operated mice. (C) Circulating CHGA concentration and human eGFR. A large cohort of healthy individuals of European ancestry were measured for plasma CHGA and eGFR. A significant negative correlation was observed suggesting decrease in glomerular function with increasing plasma CHGA concentration. (D) Ten weeks-post-Npx the BP did not differ significantly between Npx strains however, WT-Npx have significantly augmented azotemia compared to KO-Npx suggesting BP independent mechanism of CHGA pathogenesis.