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. Author manuscript; available in PMC: 2022 May 16.
Published in final edited form as: J Hypertens. 2020 Mar;38(3):456–466. doi: 10.1097/HJH.0000000000002295

Figure 6. CHGA impacts transcription of genes involved in NO synthesis and pro inflammatory markers.

Figure 6.

The mesangial cells were treated with CHGA (100 nM) or untreated for 24 hours, harvested and transcriptomes compared (A) A 2-stage amplification of transcripts involved in NO synthesis. Both the precursor Arg transporter and NO biosynthesis enzyme iNOS showed concomitant over-expression. (B) Several solute carrier transport family genes are over-expressed. Similarly, CHGA treated cells overexpress: (C) Cytokine and chemokines family transcripts (D) Complement family transcripts (E) Acute phase inflammatory markers (F) Transcripts related to cellular apoptosis.