Figure 3.

Plasma insulin, plasma glucose, and brain myoinositol concentrations—black empty circles represent the individual plasma insulin concentrations (µU/mL) (A); plasma glucose concentrations (mM) (B); pregenual anterior cingulate cortex (pgACC) myoinositol concentrations (mmol/kg brain tissue) (C); occipital cortex (OCC) myoinositol concentrations (mmol/kg brain tissue) (D) during each condition. Black filled circles and error bars represent the means ± SD of variables during each condition. Conditions: EU1 and EU2, basal euglycemia during visits 1 and 2, respectively; HG, hyperglycemic clamp during visit 1; HI, hyperinsulinemic euglycemic clamp during visit 2 with individual insulin levels matched to those of visit 1. *P < 0.05 two-sided paired t test.