Figure 5.

Relation of anterior cingulate cortex (ACC) myoinositol to functional connectivity of ACC-insula network (RSN B) with precentral cortex. A: RSN B, common to all participants and conditions, overlaid in green on the standard MNI-152 brain; regions in red-yellow scale show the precentral gyrus region where increased functional connectivity with RSN B was associated with lower pregenual anterior cingulate cortex (pgACC) myoinositol (MI) concentrations (P < 0.05). Images are shown using the radiological convention: left—sagittal (x = 0 cm); middle—coronal (y = −20 cm); right—axial (z = 6 cm). B: plot of pgACC MI concentrations vs. functional connectivity of RSN B with the precentral gyrus region for all participants and conditions. Empty shapes indicate the basal euglycemia conditions of visits 1 and 2: empty circle = visit 1, empty square = visit 2; filled shapes indicate the clamps; filled circles indicate the hyperglycemic clamp; filled squares indicate the euglycemic hyperinsulinemic clamp. The solid black line represents the linear fit of pgACC MI concentrations to functional connectivity with RSN B (Pearson R² = 0.433, P < 0.0001) and the gray area represents the 95% confidence interval.