Table 1.
Reliability of metabolite concentration estimations in pregenual anterior cingulate cortex and occipital lobe cortex
| EU1 | HG | EU2 | HI | P | |
|---|---|---|---|---|---|
| pgACC | |||||
| SNR | 19 ± 5 | 18 ± 3 | 19 ± 4 | 19 ± 4 | 0.944 |
| FWHM, Hz | 7 ± 2 | 6 ± 1 | 6 ± 1 | 6 ± 1 | 0.643 |
| CRLB MI, mM | 0.38 ± 0.09 | 0.38 ± 0.04 | 0.38 ± 0.05 | 0.36 ± 0.07 | 0.909 |
| CRLB TCr, mM | 0.21 ± 0.05 | 0.19 ± 0.03 | 0.19 ± 0.05 | 0.19 ± 0.04 | 0.586 |
| OCC | |||||
| SNR | 31 ± 5 | 29 ± 4 | 30 ± 4 | 30 ± 5 | 0.851 |
| FWHM, Hz | 5 ± 1 | 6 ± 2 | 5 ± 1 | 5 ± 1 | 0.801 |
| CRLB MI, mM | 0.26 ± 0.02 | 0.27 ± 0.02 | 0.28 ± 0.02 | 0.27 ± 0.03 | 0.224 |
| CRLB TCr, mM | 0.14 ± 0.02 | 0.15 ± 0.02 | 0.14 ± 0.2 | 0.14 ± 0.02 | 0.987 |
Values are means ± SD. CRLB, absolute Cramér-Rao lower bounds from LCModel analysis; EU1, visit 1, basal euglycemia; EU2, visit 2, basal euglycemia; FWHM, full width at half maximum from LCModel analysis; HG, visit 1, hyperglycemic clamp; HI, visit 2, matched hyperinsulinemic euglycemic clamp; MI, myoinositol; OCC, occipital lobe cortex; P, P values from one-way ANOVA across conditions; pgACC, pregenual anterior cingulate cortex; SNR, signal-to-noise ratio from LCModel analysis; TCr, total creatine (sum of creatine and phosphocreatine).