Table 2.
Concentrations of metabolites in mmol/kg of wet-weight brain tissue in pregenual anterior cingulate cortex and occipital lobe cortex
| EU1 | HG | HG—EU1 | P | EU2 | HI | HI—EU2 | P | HG-HI | P | |
|---|---|---|---|---|---|---|---|---|---|---|
| Metabolite | pgACC | |||||||||
| MI | 7.7 ± 1.5 | 6.6 ± 0.8 | −1.1 ± 1.4 | 0.031 | 7.1 ± 0.7 | 6.5 ± 0.7 | −0.6 ± 0.6 | 0.014 | 0.1 ± 0.9 | 0.663 |
| TCr | 8.3 ± 0.5 | 8.2 ± 0.7 | −0.1 ± 0.6 | 0.452 | 8.6 ± 0.7 | 8.2 ± 0.5 | −0.4 ± 0.7 | 0.133 | 0.0 ± 0.7 | 0.934 |
| Metabolite | OCC | |||||||||
| MI | 4.6 ± 0.4 | 4.6 ± 0.3 | 0.0 ± 0.4 | 0.944 | 4.8 ± 0.3 | 4.5 ± 0.5 | −0.3 ± 0.4 | 0.062 | 0.0 ± 0.3 | 0.953 |
| TCr | 6.4 ± 0.3 | 6.5 ± 0.2 | 0.1 ± 0.3 | 0.368 | 6.4 ± 0.2 | 6.5 ± 0.2 | 0.1 ± 0.2 | 0.511 | 0.1 ± 0.2 | 0.560 |
Values are means ± SD. EU1, visit 1, basal euglycemia; EU2, visit 2, basal euglycemia; HG, visit 1, hyperglycemic clamp; HG—EU1, change from EU1 to HG; HG-HI, difference between HI and HG; HI, visit 2, matched hyperinsulinemic euglycemic clamp; HI—EU2, change from EU2 to HI; MI, myoinositol; P, P values from paired t tests between conditions, P values in bold < 0.05; TCr, total creatine (sum of creatine and phosphocreatine).