Table 1.
Summary of molecules present in the FP that have been proposed to act as short-range commissural axon guidance cues.
| Name | Model | Proposed function | References |
|---|---|---|---|
| Ngcam-related CAM (Nrcam) | Mouse, chicken | Promotes growth of commissural axons across the FP | Stoeckli and Landmesser (1995) |
| Slits | Mouse, chicken | Repels post-crossing commissural axons from the FP | Brose et al. (1999), Long et al. (2004) |
| Class 3 semaphorins | Mouse, chicken | Repels post-crossing commissural axons from the FP | Nawabi et al. (2010), Zou et al. (2000) |
| Fspondin | Rat, chicken | Promotes growth of commissural axons across the FP | Burstyn-Cohen et al. (1999) |
| Neuropilin2 | Mouse | Promotes growth of commissural axons across the FP | Hernandez-Enriquez et al. (2015) |
| P84 | Mouse | Role unresolved, may serve as a substrate for axon outgrowth. | Chuang and Lagenaur (1990) |
| Neurite outgrowth inhibitor (nogo) b (reticulon4b) | Mouse | Repels post-crossing commissural axons from the FP | Wang et al. (2017) |
| Dystroglycan | Mouse | Repels post-crossing commissural axons from the FP | Wright et al. (2012) |
| Nectin3 | Mouse | Promotes for correct axon fasciculation, and rostral turn for post-crossing axons | Okabe et al. (2004) |
| MAM domain-containing glycosylphosphatidylinositol anchor (Mdga) 1 | Chicken | Function has not been characterized | Fujimura, Iwashita, Matsuzaki, and Yamamoto (2006) |
| Mdga2 | Chicken | Promotes rostral turn for post-crossing axons | Joset et al. (2011) |
| Synaptic cell adhesion molecules (Syncam)/nectin-like molecules (Necls) | Chicken | Promotes growth of commissural axons across the FP and rostral turn for post-crossing axons | Niederkofler, Baeriswyl, Ott, and Stoeckli (2010) |
| Plexina2 | Chicken | Promotes growth of commissural axons across the FP and rostral turn for post-crossing axons | Andermatt et al. (2014) |