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. Author manuscript; available in PMC: 2022 May 16.
Published in final edited form as: Curr Top Dev Biol. 2020 Nov 19;142:197–231. doi: 10.1016/bs.ctdb.2020.10.009

Table 1.

Summary of molecules present in the FP that have been proposed to act as short-range commissural axon guidance cues.

Name Model Proposed function References
Ngcam-related CAM (Nrcam) Mouse, chicken Promotes growth of commissural axons across the FP Stoeckli and Landmesser (1995)
Slits Mouse, chicken Repels post-crossing commissural axons from the FP Brose et al. (1999), Long et al. (2004)
Class 3 semaphorins Mouse, chicken Repels post-crossing commissural axons from the FP Nawabi et al. (2010), Zou et al. (2000)
Fspondin Rat, chicken Promotes growth of commissural axons across the FP Burstyn-Cohen et al. (1999)
Neuropilin2 Mouse Promotes growth of commissural axons across the FP Hernandez-Enriquez et al. (2015)
P84 Mouse Role unresolved, may serve as a substrate for axon outgrowth. Chuang and Lagenaur (1990)
Neurite outgrowth inhibitor (nogo) b (reticulon4b) Mouse Repels post-crossing commissural axons from the FP Wang et al. (2017)
Dystroglycan Mouse Repels post-crossing commissural axons from the FP Wright et al. (2012)
Nectin3 Mouse Promotes for correct axon fasciculation, and rostral turn for post-crossing axons Okabe et al. (2004)
MAM domain-containing glycosylphosphatidylinositol anchor (Mdga) 1 Chicken Function has not been characterized Fujimura, Iwashita, Matsuzaki, and Yamamoto (2006)
Mdga2 Chicken Promotes rostral turn for post-crossing axons Joset et al. (2011)
Synaptic cell adhesion molecules (Syncam)/nectin-like molecules (Necls) Chicken Promotes growth of commissural axons across the FP and rostral turn for post-crossing axons Niederkofler, Baeriswyl, Ott, and Stoeckli (2010)
Plexina2 Chicken Promotes growth of commissural axons across the FP and rostral turn for post-crossing axons Andermatt et al. (2014)