Table 2.

Intent to treat and adherence adjusted effects of low-dose aspirin on hCG detected pregnancy, live birth, and pregnancy loss among 1,227 women in the EAGeR Trial, 2006-2012. Adherence was defined as following protocol (take low dose aspirin or take placebo) 5/7 days per week.

	Risk	RD* (95% CI)	RR (95% CI)
Intent to Treat
Assigned to Placebo
Live Birth (ref)	0.48	-	-
Pregnancy Loss (ref)	0.15	-	-
hCG-Pregnancy (ref)	0.62	-	-
Assigned to Aspirin
Live Birth	0.50	3.51 (−2.13, 9.21)	1.08 (0.94, 1.19)
Pregnancy Loss	0.16	0.74 (−3.09, 4.68)	1.05 (0.74, 1.29)
hCG-Pregnancy	0.66	4.25 (−1.18, 9.56)	1.07 (0.97, 1.15)
Per Protocol
Placebo Throughout
Live Birth (ref)	0.43	-	-
Pregnancy Loss (ref)	0.20	-	-
hCG-Pregnancy (ref)	0.65	-	-
Aspirin Throughout
Live Birth	0.58	14.50 (7.65, 21.15)	1.33 (1.08, 1.64)
Pregnancy Loss	0.14	−6.10 (−12.00, −0.20)	0.69 (0.50, 0.95)
hCG-Pregnancy	0.73	7.80 (4.64, 10.96)	1.12 (1.02, 1.23)
Start at 6 Weeks
Live Birth	0.49	5.90 (0.23, 11.75))	1.14 (1.03, 1.26)
Pregnancy Loss	0.14	−5.95 (−12.93, 1.03)	0.70 (0.47, 1.04)
hCG-Pregnancy	0.63	−1.40 (−5.34, 2.54)	0.98 (0.92, 1.04)
Start at 8 Weeks
Live Birth	0.50	6.45 (1.34, 11.56)	1.15 (0.83, 1.59)
Pregnancy Loss	0.14	−5.35 (−15.70, 5.00)	0.73 (0.52, 1.03)
hCG-Pregnancy	0.65	0.10 (−4.69, 4.89)	1.00 (0.92, 1.08)
Start at 12 Weeks
Live Birth	0.49	5.95 (−0.72, 12.62)	1.14 (0.83, 1.57)
Pregnancy Loss	0.17	−3.10 (−13.96, 7.76)	0.84 (0.59, 1.21)
hCG-Pregnancy	0.66	1.60 (−3.12, 6.32)	1.02 (0.92, 1.13)
Start at 20 Weeks
Live Birth	0.47	3.85 (−1.92, 9.62)	1.09 (0.90, 1.32)
Pregnancy Loss	0.18	−1.35 (−11.83, 9.13)	0.93 (0.65, 1.33)
hCG-Pregnancy	0.66	1.30 (−4.32, 6.92)	1.02 (0.86, 1.21)

Abbreviations: RD, risk difference; RR, risk ratio; hCG, human chorionic gonadotropin.