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. 2021 Nov 3;1(2):65–78. doi: 10.1158/2767-9764.CRC-21-0073

FIGURE 5.

FIGURE 5

NURR1 regulates the expression of ATG7 and ATG12.A, qPCR analysis of ATG7 and ATG12 expression after treatment with C-DIM12 (**, P < 0.01; ***, P < 0.001). B, Immunoblot analysis of ATG7 and ATG12 and cleaved PARP in gemcitabine (GEM) and C-DIM12–treated MiaPaCa2 cells. C, Immunoblot analysis of ATG7 and ATG12 in gemcitabine and C-DIM12–treated Panc1 cells. D and E, Immunoblot analysis of cleaved PARP and p62 in the presence of si.ATG7 or si.ATG12 MiapaCa2 cells in the presence or absence of treatment with gemcitabine, C-DIM12, and combination of both. α-Tubulin serves as a loading control. F, Effects of ATG7 and ATG12 knockdown on gemcitabine-induced survival of MiaPaca2 cells was determined as outlined in Fig. 2F. Each data point represents the mean of four independent measurements.