Table 1. ALS-associated genes/proteins supported by 5 or more resources.
| Resource | Protein information | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Gene name | ALSGene (n = 17) | ALSoD (n = 111) | GAD (n = 224) | Genotator (n = 289) | HuGE GWAS (n = 118) | HuGE GeneProspector (n = 224) | Text Mining (n = 164) | UniProt entry | Protein name |
| C9ORF72 | • | • | • | • | • | • | • | CI072_HUMAN | Protein C9orf72 |
| DPP6 | • | • | • | • | • | • | DPP6_HUMAN | Dipeptidyl aminopeptidase-like protein 6 | |
| ITPR2 | • | • | • | • | • | • | ITPR2_HUMAN | Inositol 1,4,5-trisphosphate receptor type 2 | |
| KIFAP3 | • | • | • | • | • | • | KIFA3_HUMAN | Kinesin-associated protein 3 | |
| SOD1 | • | • | • | • | • | • | SODC_HUMAN | Superoxide dismutase [Cu-Zn] | |
| UNC13A | • | • | • | • | • | • | UN13A_HUMAN | Protein unc-13 homolog A | |
| ALS2 | • | • | • | • | • | ALS2_HUMAN | Alsin | ||
| ALS6, FUS | • | • | • | • | • | FUS_HUMAN | RNA-binding protein FUS | ||
| ANG | • | • | • | • | • | ANGI_HUMAN | Angiogenin | ||
| CHMP2B | • | • | • | • | • | CHM2B_HUMAN | Charged multivesicular body protein 2b | ||
| CST3 | • | • | • | • | • | CYTC_HUMAN | Cystatin-C | ||
| DCTN1 | • | • | • | • | • | DCTN1_HUMAN | Dynactin subunit 1 | ||
| DYNC1H1 | • | • | • | • | • | DYHC1_HUMAN | Cytoplasmic dynein 1 heavy chain 1 | ||
| ELP3 | • | • | • | • | • | ELP3_HUMAN | Elongator complex protein 3 | ||
| FGGY | • | • | • | • | • | FGGY_HUMAN | FGGY carbohydrate kinase domain-containing protein | ||
| HFE | • | • | • | • | • | HFE_HUMAN | Hereditary hemochromatosis protein | ||
| LIPC | • | • | • | • | • | LIPC_HUMAN | Hepatic triacylglycerol lipase | ||
| PON1 | • | • | • | • | • | PON1_HUMAN | Serum paraoxonase/arylesterase 1 | ||
| PON2 | • | • | • | • | • | PON2_HUMAN | Serum paraoxonase/arylesterase 2 | ||
| PON3 | • | • | • | • | • | PON3_HUMAN | Serum paraoxonase/lactonase 3 | ||
| PRPH | • | • | • | • | • | PERI_HUMAN | Peripherin | ||
| SMN2 | • | • | • | • | • | SMN_HUMAN | Survival motor neuron protein | ||
| SUSD1 | • | • | • | • | • | SUSD1_HUMAN | Sushi domain-containing protein 1 | ||
| TARDBP | • | • | • | • | • | TADBP_HUMAN | TAR DNA-binding protein 43 | ||
| VAPB | • | • | • | • | • | VAPB_HUMAN | Vesicle-associated membrane protein-associated protein B/C | ||
| VCP | • | • | • | • | • | TERA_HUMAN | Transitional endoplasmic reticulum ATPase | ||
| VEGF, VEGFA | • | • | • | • | • | VEGFA_HUMAN | Vascular endothelial growth factor A | ||
| VPS54 | • | • | • | • | • | VPS54_HUMAN | Vacuolar protein sorting-associated protein 54 | ||
| ZFP64 | • | • | • | • | • | ZF64A_HUMAN | Zinc finger protein 64 homolog, isoforms 1 and 2 | ||
| ZFP64 | • | • | • | • | • | ZF64B_HUMAN | Zinc finger protein 64 homolog, isoforms 3 and 4 | ||
29 proteins found in > = 1 data source. 8 out of the most frequent proteins were found in one or more of the 26 ALS core modules.