Table 3. Top 50 diseases most commonly co-mentioned with ALS in PubMed abstracts.
List of the 50 diseases most commonly co-mentioned with ALS in scientific literature. Diseases have manually been categorized into ‘Disease types’ guided by the tree structure in Disease Ontology [32, 33]. ID: Disease Ontology ID. Abbreviation: Short name for disease used in Figs 5–9. Name: Disease name in Disease Ontology. Occurences: Number PubMed abstracts mentioning disease. Co-mentionings: Number of PubMed abstracts where both disease and ALS are mentioned. Overrep. ratio: Overrepresentation ratio of co-mentionings. P-value: Significance of hypergeometric test of the overlap between disease and ALS. Disease type: Manual classification of diseases.
| ID | Abbreviation | Name | Occurrences | Co-mentionings | Overrep. ratio | P-value | Disease type |
|---|---|---|---|---|---|---|---|
| DOID:11949 | CJD | Creutzfeldt-Jakob disease | 4,508 | 61 | 14.6 | 1.59E-48 | Brain disease |
| DOID:12680 | PseudoBulbPalsy | pseudobulbar palsy | 392 | 22 | 60.5 | 7.41E-32 | |
| DOID:12859 | Chorea | choreatic disease | 3,001 | 38 | 13.7 | 7.75E-30 | |
| DOID:5702 | PleoLiposac | pleomorphic liposarcoma | 4,293 | 69 | 17.3 | 1.54E-59 | Cancer |
| DOID:3939 | LipoCanc | lipomatous cancer | 4,378 | 69 | 17.0 | 5.59E-59 | |
| DOID:769 | NeuroBlast | neuroblastoma | 27,962 | 99 | 3.8 | 5.56E-28 | |
| DOID:2476 | HS Paraplegia | hereditary spastic paraplegia | 1,690 | 103 | 65.7 | 8.73E-147 | Central nervous system disease |
| DOID:607 | Paraplegia | paraplegia | 9,017 | 114 | 13.6 | 5.10E-86 | |
| DOID:1307 | Dementia | dementia | 136,817 | 2,639 | 20.8 | ~0 | Cognitive disorder |
| DOID:9255 | FT Dementia | frontotemporal dementia | 5,737 | 1,217 | 228.8 | ~0 | |
| DOID:12217 | LB Dementia | Lewy body dementia | 3,916 | 81 | 22.3 | 4.24E-78 | |
| DOID:5408 | PBD | Paget’s disease of bone | 1,532 | 54 | 38.0 | 6.84E-65 | Connective tissue disease |
| DOID:205 | BoneHyp | hyperostosis | 6,705 | 54 | 8.7 | 5.47E-32 | |
| DOID:4953 | Poliomyelitis | poliomyelitis | 7,184 | 95 | 14.3 | 1.04E-73 | Infectious disease |
| DOID:4952 | PPMSyn | postpoliomyelitis syndrome | 535 | 35 | 70.6 | 4.20E-52 | |
| DOID:438 | AIDNeuro | autoimmune disease of the nervous system | 14,913 | 189 | 13.7 | 1.10E-141 | Immune system disease |
| DOID:12842 | GBSyn | Guillain-Barre syndrome | 6,675 | 106 | 17.1 | 5.36E-90 | |
| DOID:437 | MyaGrav | myasthenia gravis | 8,408 | 105 | 13.5 | 7.67E-79 | |
| DOID:2033 | ComDis | communication disorder | 26,572 | 129 | 5.2 | 9.33E-50 | Mental health |
| DOID:0060046 | Aphasia | aphasia | 9,060 | 57 | 6.8 | 2.56E-28 | |
| DOID:700 | MitoMetaD | mitochondrial metabolism disease | 5,245 | 45 | 9.3 | 4.82E-28 | Metabolic disease |
| DOID:683 | MotorNeu | motor neuritis | 1,915 | 139 | 78.3 | 2.97E-208 | Motor neuron disease |
| DOID:681 | ProgBulbPalsy | progressive bulbar palsy | 432 | 97 | 242.2 | 1.37E-196 | |
| DOID:0060161 | SBMA | Kennedy’s disease | 787 | 96 | 131.6 | 6.91E-167 | |
| DOID:678 | ProgSupraPalsy | progressive supranuclear palsy | 2,782 | 119 | 46.1 | 7.26E-151 | Movement disease |
| DOID:767 | MuscAtrophy | muscular atrophy | 14,482 | 897 | 66.8 | ~0 | Muscle tissue disease |
| DOID:3429 | IncBodyMyositis | inclusion body myositis | 1,525 | 88 | 62.2 | 1.52E-123 | |
| DOID:11722 | MyoDystT1 | myotonic dystrophy type 1 | 3,772 | 74 | 21.2 | 7.35E-70 | |
| DOID:11723 | DuchMuscDys | Duchenne muscular dystrophy | 7,844 | 82 | 11.3 | 4.30E-56 | |
| DOID:12858 | HD | Huntington’s disease | 11,696 | 642 | 59.2 | ~0 | Neurodegenerative disease |
| DOID:14330 | PD | Parkinson’s disease | 69,957 | 1,725 | 26.6 | ~0 | |
| DOID:10652 | AD | Alzheimer’s disease | 92,611 | 1,658 | 19.3 | ~0 | |
| DOID:2377 | MS | multiple sclerosis | 49,375 | 686 | 15.0 | ~0 | |
| DOID:2478 | SC Degen | spinocerebellar degeneration | 8,342 | 232 | 30.0 | 1.35E-249 | |
| DOID:1441 | SC Ataxia | spinocerebellar ataxia | 7,104 | 211 | 32.0 | 4.70E-233 | |
| DOID:11870 | PickD | Pick’s disease | 976 | 65 | 71.8 | 7.94E-96 | |
| DOID:9277 | PC Degen | primary cerebellar degeneration | 1,134 | 48 | 45.7 | 1.14E-61 | |
| DOID:12705 | FR Ataxia | Friedreich ataxia | 2,119 | 56 | 28.5 | 2.50E-60 | |
| DOID:10595 | CMTD | Charcot-Marie-Tooth disease | 8,334 | 647 | 83.7 | 0 | Neuromuscular disease |
| DOID:3602 | ToxEnceph | toxic encephalopathy | 26,094 | 293 | 12.1 | 1.44E-204 | Nervous system disease |
| DOID:12697 | LockedInSyn | locked-in syndrome | 5,900 | 72 | 13.2 | 6.12E-54 | |
| DOID:913 | AtroMuscD | atrophic muscular disease | 5,802 | 575 | 106.9 | ~0 | Peripheral nervous system |
| DOID:5214 | DemyelinPN | demyelinating polyneuropathy | 3,391 | 69 | 22.0 | 2.59E-66 | |
| DOID:5213 | CIDMPRN | chronic inflammatory demyelinating polyradiculoneuropathy | 2,061 | 51 | 26.7 | 1.14E-53 | |
| DOID:4308 | PR Neuropathy | polyradiculoneuropathy | 9,689 | 74 | 8.2 | 1.09E-41 | |
| DOID:2491 | SP Neuropathy | sensory peripheral neuropathy | 3,520 | 41 | 12.6 | 1.12E-30 | |
| DOID:11162 | Resp. Failure | respiratory failure | 57,385 | 418 | 7.9 | 1.53E-220 | Respiratory system disease |
| DOID:2733 | Skin Atrophy | skin atrophy | 12,885 | 80 | 6.7 | 1.16E-38 | Skin disease |
| DOID:318 | ProgMusc atrophy | progressive muscular atrophy | 303 | 141 | 501.9 | ~0 | Spinal cord disease |
| DOID:0050881 | IBMPFD | inclusion body myopathy with Paget disease of bone and frontotemporal dementia | 105 | 26 | 267.1 | 3.84E-55 | Syndrome |