Table 2.
Transmission blocking activity of sera from BALB/c mice sera after immunization with E. coli and CHO rPvs48/45 proteins.
| Adjuvant | Best estimates of %TRA from two assays to E. coli- rPvs48/45a |
Best estimates of %TRA from two assays to CHO-rPvs48/45a |
E. coli vs. CHO- rPvs48/45 |
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|---|---|---|---|---|---|---|---|
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| %TRA | (95%CI) | p-value | %TRA | (95%CI) | p-value | p-value | |
| Alhydrogel | 48.1 | (7 to 72) | 0.030 | 42.5 | (−2 to 68) | 0.057 | 0.718 |
| GLA-SE | 38.0 | (−10 to 65) | 0.111 | 61.2 | (29 to 79) | 0.002 | 0.150 |
| Montanide | 57.8 | (24 to 77) | 0.005 | 90.8 | (82 to 96) | <0.001 | <0.001 |
a
The best estimate of % inhibition in oocyst density (%TRA) at 95% confidence intervals (95%CI), and p-value for antisera were calculated against Normal AB+ sera using a zero-inflated negative binomial model as described previously [32]