Fig. 5.

Membrane binding by ACE2-bound spike trimers. A. The heatmap shows the membrane binding propensity of each residue in the various ACE2 complexed SARS-CoV-2 structures for the indicated PDB entries collected at the various pH values. The ACE2 bound and free states of each subunit structure are shown with black and light grey circles below the heatmap, as are the RBD positions. B. The structure of the spike protein is shown as a surface with a, b, and c subunits in blue, green and yellow, with the three bound ACE2 proteins shown as ribbons with similar, lighter colors. The residues with moderate and substantial MODA scores are shown in pink and red, respectively, and are labelled as are the C-termini. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)