Table III.
Univariable and multivariable logistic regression results
| Variables | Univariable OR (CI) | P valuea | Multivariable OR (CI), n = 786 | P valueb |
|---|---|---|---|---|
| Age | 1.013 (1.00, 1.028) | 0.056 | 1.006 (0.988, 1.024) | 0.554 |
| Male | 1.492 (0.94, 2.369) | 0.090 | 1.333 (0.807, 2.201) | 0.262 |
| Race/Ethnicity | ||||
| BNH versus WNH | 2.16 (1.04, 4.46) | 0.038 | 1.940 (0.886, 4.248) | 0.097 |
| Hispanic versus WNH | 1.44 (0.72, 2.88) | 0.298 | 2.237 (1.053, 4.754) | 0.036 |
| Other versus WNH | 0.89 (0.24, 3.33) | 0.860 | 1.141 (0.293, 4.438) | 0.849 |
| Previous or current smoker | 1.154 (0.666, 2.001) | 0.610 | ||
| Diabetes | 1.26 (0.805, 1.973) | 0.311 | ||
| CKD | 1.401 (0.783, 2.509) | 0.256 | ||
| End-stage renal disease | 1.563 (0.788, 3.101) | 0.201 | ||
| Hypertension | 1.779 (1.064, 2.975) | 0.028 | 1.15 (0.609, 2.171) | 0.700 |
| Hyperlipidemia | 1.233 (0.785, 1.937) | 0.364 | ||
| Coronary artery disease | 1.762 (1.061, 2.927) | 0.029 | 0.963 (0.488, 1.900) | 0.917 |
| Myocardial infraction | 1.973 (0.984, 3.956) | 0.056 | 1.636 (0.698, 3.834) | 0.239 |
| Congestive heart failure | 0.956 (0.49, 1.866) | 0.896 | ||
| Peripheral artery disease | 1.597 (0.648, 3.936) | 0.309 | ||
| Chronic limb-threatening Ischemia | 4.289 (1.264, 14.551) | 0.020 | 2.757 (0.662, 11.48) | 0.181 |
| COPD | 1.909 (0.926, 3.934) | 0.080 | 1.401 (0.598, 3.285) | 0.487 |
| Respiratory failure | 1.509 (0.567, 4.016) | 0.410 | ||
| Previous PE | 1.192 (0.348, 4.082) | 0.780 | ||
| Previous DVT | 2.136 (0.994, 4.592) | 0.052 | 1.087 (0.426, 2.773) | 0.814 |
| Ischemic stroke | 1.415 (0.717, 2.794) | 0.317 | ||
| Any antiplatelet | 2.375 (1.513, 3.726) | <0.001 | 1.775 (1.022, 3.084) | 0.041 |
| Any anticoagulationc | 7.525 (1.03, 54.952) | 0.047 | ||
| Elevated creatinined | 1.972 (1.24, 3.14) | 0.004 | 1.455 (0.721, 2.936) | 0.354 |
| D-DIMER, per 500-unit increase | 1.055 (1.031, 1.079) | <0.0001 | 1.052 (1.027, 1.077) | <0.001 |
| BUN, per 5-unit increase | 1.053 (1.006, 1.102) | 0.028 | 0.981 (0.91, 1.058) | 0.615 |
P values < 0.10 are highlighted. BNH, Black Non-Hispanic; WNH, White Non-Hispanic.
P value calculated with a complete-case simple logistics regression model.
P value calculated in complete-case multivariable logistics regression model with all variables presented in the previous column as predictors. This model also included a missing data indicator for D-Dimer, results not presented. Pairwise comparisons between race groups not presented are not statistically significant (P > 0.05).
Any anticoagulation use was not included in the final multivariable model, despite being significant at the P < 0.10 due to a lack of variability.
Creatinine was not linearly associated with the outcome. Therefore, was dichotomized at value 1.4 to indicate ‘Elevated Creatinine’.