Corrigendum

In [1], the authors would like to publish revised Figures 2 and 3 as there are some changes in the final row [LOH (Y/N)] of the tables relating to Figures 2B and 3A.

FIGURE 2.

Single‐nucleotide polymorphism (SNP) arrays of low hypodiploid (A) and near triploid cases (B) (whole genome view of SNP arrays and whole chromosome log2 ratios, shown to two decimal places). (A) Example of a low hypodiploid case (#27069, blast percentage 96%) where only a low hypodiploid clone was detected on karyotype. Reduced log2 ratios are seen in chromosomes with complete loss of heterozygosity (LOH) on B‐allele frequency trace (LOH‐lower copy number [LCN]) and elevated log2 ratios in chromosomes with preserved disomic pattern of SNPs on B‐allele frequency. (B) Example case (#25437, blast percentage 88%) where only a near triploid clone was detected on karyotype. Reduced log2 ratios are seen in chromosomes with complete LOH on B‐allele frequency trace (LOH‐LCN) and elevated log2 ratios in chromosomes without LOH

FIGURE 3.

Single‐nucleotide polymorphism (SNP) arrays of cytogenetically misclassified (A) and visually inconclusive (B) cases (whole genome view of SNP arrays and whole chromosome log2 ratios, shown to two decimal places). (A) Example case (#27478, blast percentage 88%) cytogenetically classified as high hyperdiploidy with conflicting SNP array profile. SNP array demonstrates complete loss of heterozygosity (LOH) of chromosomes with the lowest copy number state (LOH‐lower copy number [LCN]). Other chromosomes show a trisomic complement of SNPs. Overall, the pattern observed is similar to that seen in low hypodiploid/near triploid (HoTr) cases, contradicting initial cytogenetic subgroup despite modal chromosome number. (B) Example near triploid case (#28056, blast percentage 90%) with an inconclusive SNP array. The appearances would typically be associated with nonleukemic DNA contamination, although blast percentage in the diagnostic sample was high. The karyotype contains five tetrasomies and a duplicated structural abnormality consistent with HoTr. Although the log2 ratio and B‐allele frequency traces appear almost normal, the whole chromosome log2 ratio of chromosomes 3, 7, 15, 16, 17, 19, and 20 (which are frequently monosomic in low hypodiploidy) is reduced. When standardized, whole chromosome log2 ratios correctly clustered with the HoTr cases (Figure 4)

The new figures are as follows: