Table 2. Characteristics of patients with associated endocrine diseases ( n  = 12) .

Characteristic		Frequency	Percentage
Mean of age (y)		20.28 ± 20.67
Gender: male to female ratio		4:1	75:25
Consanguinity	Positive	7	58.30
	Negative	5	41.70
Mode of mutation	Sporadic	7	58.30
	Familial	5	41.70
Sporadic and consanguineous		5	41.70
Familial and consanguineous		2	16.67
NF-1 mutation	Pathogenic variant	8	66.67
	Likely pathogenic	2	16.67
	Variants of uncertain significance	2	16.67