Table 2.
Characteristics of common targets.
| No. | Target | Symbol | UniProt ID | No. | Target | Symbol | UniProt ID |
|---|---|---|---|---|---|---|---|
| 1 | 72 kDa type IV collagenase | MMP2 | P08253 | 76 | Prostaglandin E2 receptor EP3 subtype | PTGER3 | P43115 |
| 2 | Xanthine dehydrogenase/oxidase | XDH | P47989 | 77 | Urokinase-type plasminogen activator | PLAU | P00749 |
| 3 | Heat shock protein beta-1 | HSPB1 | P04792 | 78 | Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | PTEN | P60484 |
| 4 | Nitric oxide synthase, inducible | NOS2 | P35228 | 79 | Sodium-dependent serotonin transporter | SLC6A4 | P31645 |
| 5 | Hepatocyte growth factor receptor | MET | P08581 | 80 | Interferon regulatory factor 1 | IRF1 | P10914 |
| 6 | UDP-glucuronosyltransferase 1–1 | UGT1A1 | P22309 | 81 | Arachidonate 5-lipoxygenase | ALOX5 | P09917 |
| 7 | Protein kinase C beta type | PRKCB | P05771 | 82 | Gap junction alpha-1 protein | GJA1 | P17302 |
| 8 | Collagen alpha-1(I) chain | COL1A1 | P02452 | 83 | Claudin-4 | CLDN4 | O14493 |
| 9 | Baculoviral IAP repeat-containing protein 5 | BIRC5 | O15392 | 84 | Dipeptidyl peptidase IV | DPP4 | P27487 |
| 10 | Apoptosis regulator Bcl-2 | BCL2 | P10415 | 85 | Serum paraoxonase/arylesterase 1 | PON1 | P27169 |
| 11 | Alpha-2A adrenergic receptor | ADRA2A | P08913 | 86 | Caspase-8 | CASP8 | Q14790 |
| 12 | Cytochrome P450 1A1 | CYP1A1 | P04798 | 87 | Peroxisome proliferator activated receptor gamma | PPARG | P37231 |
| 13 | 5-Hydroxytryptamine receptor 3A | HTR3A | P46098 | 88 | C-X-C motif chemokine 11 | CXCL11 | O14625 |
| 14 | Mitogen-activated protein kinase 10 | MAPK10 | P53779 | 89 | Interleukin-8 | CXCL8 | P10145 |
| 15 | Prostaglandin E synthase | PTGES | O14684 | 90 | E-selectin | SELE | P16581 |
| 16 | C-reactive protein | CRP | P02741 | 91 | Thrombomodulin | THBD | P07204 |
| 17 | Glutathione S-transferase P | GSTP1 | P09211 | 92 | Glucocorticoid receptor | NR3C1 | P04150 |
| 18 | Aryl hydrocarbon receptor | AHR | P35869 | 93 | Serine/threonine-protein kinase mTOR | MTOR | P42345 |
| 19 | Nuclear factor erythroid 2-related factor 2 | NFE2L2 | Q16236 | 94 | Mitogen-activated protein kinase 14 | MAPK14 | Q16539 |
| 20 | Tumor necrosis factor | TNF | P01375 | 95 | RAF proto-oncogene serine/threonine-protein kinase | RAF1 | P04049 |
| 21 | Pro-epidermal growth factor | EGF | P01133 | 96 | Cytosolic phospholipase A2 | PLA2G4A | P47712 |
| 22 | Interleukin-1 alpha | IL1A | P01583 | 97 | Myeloperoxidase | MPO | P05164 |
| 23 | Canalicular multispecific organic anion transporter 1 | ABCC2 | Q92887 | 98 | Alpha-1B adrenergic receptor | ADRA1B | P35368 |
| 24 | Caspase-1 | CASP1 | P29466 | 99 | Inhibitor of nuclear factor kappa-B kinase subunit alpha | CHUK | O15111 |
| 25 | Osteopontin | SPP1 | P10451 | 100 | Signal transducer and activator of transcription 3 | STAT3 | P40763 |
| 26 | Thrombin | F2 | P00734 | 101 | Antileukoproteinase | SLPI | P03973 |
| 27 | Prostaglandin G/H synthase 2 | PTGS2 | P35354 | 102 | Cathepsin D | CTSD | P07339 |
| 28 | Catenin beta-1 | CTNNB1 | P35222 | 103 | Sterol O-acyltransferase 1 | SOAT1 | P35610 |
| 29 | G1/S-specific cyclin-D1 | CCND1 | P24385 | 104 | Acetylcholinesterase | ACHE | P22303 |
| 30 | Estrogen receptor | ESR1 | P03372 | 105 | Induced myeloid leukemia cell differentiation protein Mcl-1 | MCL1 | Q07820 |
| 31 | Vascular endothelial growth factor A | VEGFA | P15692 | 106 | C-C motif chemokine 2 | CCL2 | P13500 |
| 32 | Transforming growth factor beta-1 | TGFB1 | P01137 | 107 | Interleukin-6 | IL6 | P05231 |
| 33 | Myc proto-oncogene protein | MYC | P01106 | 108 | Caspase-3 | CASP3 | P42574 |
| 34 | Cyclin-A2 | CCNA2 | P20248 | 109 | Heat shock protein HSP 90-alpha | HSP90AA1 | P07900 |
| 35 | Glycogen synthase kinase-3 beta | GSK3B | P49841 | 110 | Poly [ADP-ribose] polymerase 1 | PARP1 | P09874 |
| 36 | Interstitial collagenase | MMP1 | P03956 | 111 | Tumor necrosis factor ligand superfamily member 6 | FASLG | P48023 |
| 37 | Signal transducer and activator of transcription 1-alpha/beta | STAT1 | P42224 | 112 | Maltase-glucoamylase, intestinal | MGAM | O43451 |
| 38 | Peroxisome proliferator activated receptor delta | PPARD | Q03181 | 113 | Vascular endothelial growth factor receptor 2 | KDR | P35968 |
| 39 | 3-Hydroxy-3-methylglutaryl-coenzyme a reductase | HMGCR | P04035 | 114 | Fos-related antigen 2 | FOSL2 | P15408 |
| 40 | Mineralocorticoid receptor | NR3C2 | P08235 | 115 | ATP-binding cassette sub-family G member 2 | ABCG2 | Q9UNQ0 |
| 41 | Glutathione reductase, mitochondrial | GSR | P00390 | 116 | Peroxisome proliferator-activated receptor alpha | PPARA | Q07869 |
| 42 | Heme oxygenase 1 | HMOX1 | P09601 | 117 | Cytochrome P450 1A2 | CYP1A2 | P05177 |
| 43 | Stromelysin-1 | MMP3 | P08254 | 118 | Insulin-like growth factor II | IGF2 | P01344 |
| 44 | Pituitary adenylate cyclase-activating polypeptide | ADCYAP1 | P18509 | 119 | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform | PIK3CG | P48736 |
| 45 | Glutathione S-transferase mu 1 | GSTM1 | P09488 | 120 | NAD(P)H dehydrogenase [quinone] 1 | NQO1 | P15559 |
| 46 | Interleukin-10 | IL10 | P22301 | 121 | Interleukin-2 | IL2 | P60568 |
| 47 | Mitogen-activated protein kinase 1 | MAPK1 | P28482 | 122 | Receptor tyrosine-protein kinase erbB-3 | ERBB3 | P21860 |
| 48 | C-X-C motif chemokine 2 | CXCL2 | P19875 | 123 | Interferon gamma | IFNG | P01579 |
| 49 | Epidermal growth factor receptor | EGFR | P00533 | 124 | Proto-oncogene c-Fos | FOS | P01100 |
| 50 | Inhibitor of nuclear factor kappa-B kinase subunit beta | IKBKB | O14920 | 125 | 78 kDa glucose-regulated protein | HSPA5 | P11021 |
| 51 | Superoxide dismutase [Cu-Zn] | SOD1 | P00441 | 126 | Intercellular adhesion molecule 1 | ICAM1 | P05362 |
| 52 | Receptor tyrosine-protein kinase erbB-2 | ERBB2 | P04626 | 127 | Caveolin-1 | CAV1 | Q03135 |
| 53 | Interleukin-4 | IL4 | P05112 | 128 | Bcl-2-like protein 1 | BCL2L1 | Q07817 |
| 54 | Mitogen-activated protein kinase 8 | MAPK8 | P45983 | 129 | Mitogen-activated protein kinase 3 | MAPK3 | P27361 |
| 55 | Aldose reductase | AKR1B1 | P15121 | 130 | Carbonic anhydrase II | CA2 | P00918 |
| 56 | Histamine H1 receptor | HRH1 | P35367 | 131 | Transcription factor p65 | RELA | Q04206 |
| 57 | Cell division protein kinase 2 | CDK2 | P24941 | 132 | Hypoxia-inducible factor 1-alpha | HIF1A | Q16665 |
| 58 | Progesterone receptor | PGR | P06401 | 133 | Nitric-oxide synthase, endothelial | NOS3 | P29474 |
| 59 | Ornithine decarboxylase | ODC1 | P11926 | 134 | Mu-type opioid receptor | OPRM1 | P35372 |
| 60 | C-X-C motif chemokine 10 | CXCL10 | P02778 | 135 | Plasminogen activator inhibitor 1 | SERPINE1 | P05121 |
| 61 | Cellular tumor antigen p53 | TP53 | P04637 | 136 | Vascular cell adhesion protein 1 | VCAM1 | P19320 |
| 62 | Caspase-9 | CASP9 | P55211 | 137 | RAC-alpha serine/threonine-protein kinase | AKT1 | P31749 |
| 63 | Cyclin-dependent kinase inhibitor 1 | CDKN1A | P38936 | 138 | Prostaglandin G/H synthase 1 | PTGS1 | P23219 |
| 64 | Catalase | CAT | P04040 | 139 | Tissue factor | F3 | P13726 |
| 65 | NAD-dependent deacetylase sirtuin-1 | SIRT1 | Q96EB6 | 140 | Nuclear receptor sub-family 1 group I member 2 | NR1I2 | O75469 |
| 66 | Multidrug resistance-associated protein 1 | ABCC1 | P33527 | 141 | Transcription factor AP-1 | JUN | P05412 |
| 67 | Interleukin-1 beta | IL1B | P01584 | 142 | Androgen receptor | AR | P10275 |
| 68 | NF-kappa-B inhibitor alpha | NFKBIA | P25963 | 143 | Apoptosis regulator BAX | BAX | Q07812 |
| 69 | Insulin-like growth factor-binding protein 3 | IGFBP3 | P17936 | 144 | Protein kinase C alpha type | PRKCA | P17252 |
| 70 | Serum albumin | ALB | P02768 | 145 | CD40 ligand | CD40LG | P29965 |
| 71 | 5-Hydroxytryptamine 2A receptor | HTR2A | P28223 | 146 | Cytochrome P450 3A4 | CYP3A4 | P08684 |
| 72 | Stromelysin-2 | MMP10 | P09238 | 147 | Matrix metalloproteinase-9 | MMP9 | P14780 |
| 73 | Estrogen receptor beta | ESR2 | Q92731 | 148 | Adiponectin | ADIPOQ | Q15848 |
| 74 | Cytochrome P450 1B1 | CYP1B1 | Q16678 | 149 | Retinoic acid receptor RXR-beta | RXRB | P28702 |
| 75 | Neuronal acetylcholine receptor protein, alpha-7 chain | CHRNA7 | P36544 |