Table 3.

Effect of crude extract and solvent fractions of the Withania somnifera leaves on castor oil-induced enteropooling

Dose (mg/kg)	MVIC (g)	% inhibition	MWIC (ml)	% inhibition
NC	0.70 ± 0 0.01	—	0.78 ± 0.04	—
Lop	0.29 ± 0.01a3	59.14	0.34 ± 0.01a3	56.83
100CE	0.54 ± 0.02a1b3c3	23.04	0.58 ± 0.02a1b3c3	25.64
200CE	0.39 ± 0.01a3b1	44.42	0.42 ± 0.05a3b1	45.94
400CE	0.30 ± 0.01a3	57.25	0.35 ± 0.02a3	54.91
100CF	0.67 ± 0.01b3c3	4.52	0.72 ± 0.01b3c3	7.69
200 CF	0.63 ± 0.01b3c3	9.75	0.71 ± 0.01b3c3	9.40
400CF	0.47 ± 0.01a3b3c3	33.02	0.52 ± 0.02a3b3c3	33.33
100BF	0.65 ± 0.03b3c3	7.13	0.69 ± 0.01b3c3	11.32
200BF	0.46 ± 0.02a2b3c3	34.44	0.51 ± 0.02a2b3c3	34.62
400BF	0.37 ± 0.01a3b2c1	47.27	0.44 ± 0.01a3b1	46.15
100AF	0.60 ± 0.01b3c3	14.49	0.64 ± 0.01b3c3	37.18
200AF	0.42 ± 0.04a3b3c3	40.15	0.43 ± 0.03a3b2c2	44.87
400AF	0.34 ± 0.02a3	51.55	0.39 ± 0.02a3	49.58

The result is expressed as mean ± standard error of the mean; n = 6. ^acompared to negative control, ^bnegative compared to 3 mg/kg loperamide, ^ccompared to 400 mg/kg crude extract; ¹p < 0.05, ²p < 0.01, ³p < 0.001. MVIC: mean volume of intestinal content, MWIC: mean weight of intestinal content, NC: negative control (10 ml/kg of 2% Tween 80 in distilled water), CE: crude extract, Lop: 3 mg/kg loperamide, CF: chloroform fraction, BF: n-butanol fraction, AF: aqueous fraction.