Table 4.
Effects of crude extract and solvent fractions of Withania somnifera leaves on castor oil-induced gastrointestinal motility in mice.
| Dose given (mg/kg) | LSI (cm) | DTCM (cm) | PI | % inhibition |
|---|---|---|---|---|
| NC | 58.5834 ± 0.32 | 44.4934 ± 0.85 | 75.9834 ± 1.75 | — |
| Lop | 56.5834 ± 0.94 | 16.8034 ± 1.22 a3 | 29.7134 ± 2.13a3 | 60.89 |
| 100 CE | 58.6134 ± 0.43 | 35.5234 ± 0.90a3b2c3 | 61.3634 ± 1.71a2b3c3 | 19.23 |
| 200 CE | 58.2534 ± 0.52 | 25.3034 ± 1.60a3b2c2 | 43.4634 ± 2.81a3b2c1 | 42.8 |
| 400 CE | 55.6834 ± 1.08 | 17.5534 ± 1.64a3 | 31.613.12a3 | 58.39 |
| 100CF | 58.0534 ± 0.98 | 44.4234 ± 1.11b3c3 | 76.50.70b3c3 | 7.84 |
| 200CF | 58.7234 ± 0.64 | 39.2234 ± 0.57b3c3 | 66.8734 ± 0.95b3c3 | 11.98 |
| 400CF | 59.2234 ± 0.50 | 31.5934 ± 1.41a3b3c3 | 53.3234 ± 2.21a3b3c3 | 29.82 |
| 100BF | 58.6534 ± 0.45 | 39.4834 ± 1.10 b3c3 | 67.3234 ± 1.53b2c3 | 11.39 |
| 200BF | 58.4934 ± 0.52 | 32.9734 ± 0.94a3b3c3 | 56.3834 ± 1.63a3b3c2 | 25.79 |
| 400BF | 58.1634 ± 0.83 | 25.7734 ± 0.76 a3b3C2 | 44.4234 ± 1.84a3b2c1 | 41.54 |
| 100AF | 57.8934 ± 0.75 | 36.9034 ± 0.7b3c3 | 64.7034 ± 1.06b3c3 | 14.85 |
| 200AF | 58.3434 ± 0.38 | 27.3134 ± 1.06a3b3c3 | 46.8634 ± 1.96a3b3c3 | 38.32 |
| 400AF | 58.4834 ± 0.47 | 20.8434 ± 0.97a3 | 35.6034 ± 1.44a3 | 53.14 |
The results are expressed as mean ± standard error of mean (n = 6). acompared to negative control, bcompared to positive control, ccompared to 400 mg/kg. NC: negative controls (10 ml/kg 2% Tween 80 in distilled water), CE: crude extract, Lop: 3 mg/kg loperamide, CF: chloroform fraction, BF: n-butanol fraction, AF: aqueous fraction, LSI: length of small intestine, DTCM: distance traveled by charcoal meal, PI: peristalsis index. 1p < 0.05, 2p < 0.01, 3p < 0.001.