Table 5.
In vivo antidiarrheal index of the crude extract and solvent fractions of the Withania somnifera leaves in mice.
| Dose (mg/kg) | Delay in defecation (onset of time in min) | Gut meal travel distance (Gmeq) | Purging frequency (%) (in number of wet stools) | In vivo antidiarrheal index (ADI) |
|---|---|---|---|---|
| NC | — | — | — | — |
| Lop | 93.39 | 60.89 | 82.35 | 77.65 |
| 100CE | 21.11 | 19.23 | 29.41 | 22.86 |
| 200CE | 55.73 | 42.8 | 56.86 | 32.9 |
| 400CE | 87.53 | 58.39 | 80.39 | 74.34 |
| 100CF | 10.18 | 7.84 | 7.84 | 8.55 |
| 200CF | 22.40 | 11.98 | 19.61 | 17.39 |
| 400CF | 44.27 | 29.82 | 45.1 | 39.05 |
| 100BF | 15.27 | 11.39 | 17.65 | 14.53 |
| 200BF | 33.08 | 25.79 | 27.41 | 28.6 |
| 400BF | 69.21 | 41.54 | 60.78 | 55.91 |
| 100AF | 16.03 | 14.85 | 23.53 | 17.76 |
| 200AF | 50.89 | 38.32 | 50.98 | 46.32 |
| 400AF | 73.79 | 53.14 | 62.74 | 62.66 |
NC: negative controls, CE: crude extract, Lop: 3 mg/ml loperamide, CF: chloroform fraction, BF: n-butanol fraction, AF: aqueous fraction.