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. Author manuscript; available in PMC: 2022 Jun 14.
Published in final edited form as: Cancer Cell. 2021 Jun 14;39(6):793–809.e8. doi: 10.1016/j.ccell.2021.05.008

Figure 2. Unique Molecular subtypes of UTUC.

Figure 2.

(A) Statistically significant (q < 0.1) positive (red) and negative (blue) correlations across common genetic lesions in non-hypermutated UTUC (Fisher’s exact test with Benjamini-Hochberg adjustment). (B) Statistically significant (q < 0.1, two-sided Fisher’s exact test with Benjamini-Hochberg adjustment) pairwise comparison of difference in MCFs between indicated gene pairs. (C) Landscape of somatic alterations in 199 UTUC cases grouped into five discrete subtypes. Significantly mutated (MutSigCV) and/or positively selected (dNdScv) driver genes are indicated by asterisks. At the bottom are SBS signatures. RTK, receptor tyrosine kinase; PI3K, phosphatidylinositol 3-kinase.

See also Table 1 and Figure S4.