Extended Data Fig. 2. Within-sibship shrinkage for educational attainment across European ancestry cohorts.
AMDTSS = Australian Mammographic Density Twin Study, DTR = Danish Twins Registry, NTR = Netherlands Twin Registry, QIMR = QIMR Berghofer Medical Research Institute (QIMR).Extended Data Figure 2 shows estimates of within-sibship shrinkage and 95% confidence intervals for educational attainment variants in all of the cohorts contributing to the European meta-analysis as well as the meta-analysis GWAS. Shrinkage is defined as the % decrease in association between the relevant weighted score and phenotype when comparing the population estimate to the within-sibship estimate. Shrinkage was computed as the ratio of two weighted score association estimates with standard errors derived using leave-one-out jackknifing. These estimates used the weighted score for each phenotype at the more liberal threshold (P < 1×10−5). The total number of individuals in the meta-analysis was n = 128,777 with individual study sample sizes ranging from n = 742 for STR Psych Cohort 1 to n = 39,531 for UK Biobank. Further information on samples with educational attainment data in each cohort are contained in Supplementary Table 1.