Table 2.
List of Omicron RBD mutations. The mutations are numbered according to the full spike protein length or the RBD residue number. The mutant residue is assigned as new or conserved if found in another SARS-CoV-2 variant.
| Mutation in Omicron (full spike numbering) | Mutation in Omicron (RBD residue no.) | New/conserved mutation | Conserved with other virus |
|---|---|---|---|
| G339D | G6D | New | |
| S371L | S38L | New | |
| S373P | S40P | New | |
| S375F | S42F | New | |
| K417N | K84N | Conserved | Mu variant, Beta variant |
| N440K | N107K | New | |
| G446S | G113S | New | |
| S477N | S144N | New | |
| T578K | T145K | Conserved | SARS-CoV-2, Delta variant |
| E484A | E151A | New | |
| Q493R | Q160R | New | |
| G496S | G163S | New | |
| Q498R | Q165R | New | |
| N501Y | N168Y | Conserved | Alpha variant, Beta variant, Gamma variant, Mu variant |
| Y505H | Y172H | New |