Fig. 1. Pre- and post-treatment urinary excretion of markers of DNA and RNA damage from oxidation, 8-oxodG (blue) and 8-oxoGuo (red), respectively, in one hundred antidepressant drug-free patients with unipolar depression treated with a serotonergic antidepressant (escitalopram/duloxetine) for 8 weeks.

Data are showed as individual data points, means, and standard deviations, and were analyzed with paired t-tests. ****p < 0.0001, ***p < 0.001.