Table 2.

Urinary excretion of markers of DNA and RNA damage from oxidation, 8-oxodG and 8-oxoGuo (nmol/mmol creatinine), respectively, in the full control population, the age- and sex-matched control population, and in one hundred antidepressant drug-free patients with unipolar depression pre- and post-treatment with a serotonergic antidepressant (escitalopram/duloxetine) for 8 weeks.

	Controls, full (N = 856)	Controls, matched (N = 67)	Patients (baseline) (N = 100)	Patients (week 8) (N = 82)
8-oxodG	1.6 (0.7)	1.6 (0.8)	1.7 (0.7)	1.2 (0.5)*,**
8-oxoGuo	1.9 (0.6)	1.8 (0.5)	1.6 (0.4)*	1.4 (0.3)*,**

Data are showed as means and standard deviations and were analyzed with independent or paired t-tests, as appropriate.

*Significantly different from both control groups (p < 0.001).

**Significantly different from pre-treatment (p < 0.001).