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. 2022 May 16;12:8031. doi: 10.1038/s41598-022-11891-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Macroscopic alterations and histopathology of endometriosis-like lesions after treatment with ASCs. (A) Representative excised implants from the endometriosis-like lesions. The interval at the bottom represents 1 mm. (B–D) Representative images of pathological specimens from excised implants stained with hematoxylin and eosin (B), Masson’s trichrome (C), and Ki67 (D). The red arrow in (B) indicates the maximum stromal thickness from the bottom of the endometrium to the surface of each cyst. The blue and red stains in (C) indicate collagen fibers and cells (mainly: fibroblasts) in the endometriosis-like lesions. (E) Quantification of maximum stromal thickness from the bottom of the endometrium to the surface of each cyst (top) and the percentage of Ki67-positive cells stained in the endometriotic epithelial cells (bottom). Data are presented as the mean ± standard error. *P < 0.01 vs. Control.