Fig. 10. In vivo biosafety and antitumor recurrence effect of PCP-Mn-DTA@GOx@1-MT nanosystem.
a Changes in the blood glucose level after 1 h post-treatment. b Procedures of the treatment to study the recurrence degree of tumor. c, c’ Tumor recurrence ratio of B16F10 and 4T1 tumor-bearing mice after various treatments. d, d’ FCM and (e, e’) corresponding quantitative analysis on the frequency of TEM and TCM cells in the spleen at day 8 when re-challenging mice with secondary B16F10 and 4T1 tumors. Data represent mean ± SD (n = 6 biologically independent samples). P-values were determined by unpaired Student’s t-test (two-tailed), **p < 0.01. Box plots indicate median (middle line), 25th and 75th percentile (box), and 5th and 95th percentile (whiskers), as well as outliers (single points).