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. 2022 May 16;13:2688. doi: 10.1038/s41467-022-30436-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — a, a’ Photographs of B16F10 (a) and 4T1 (a’) tumor-bearing mice after treatments with saline, Mn-DTA, PCP-Mn-DTA, GOx, 1-MT, PCP-Mn-DTA@1-MT, and PCP-Mn-DTA@GOx@1-MT for 0, 7, and 18 d, respectively. b, b’ Tumor volumes and (c, c’) survival rates of mice after various treatments. d, d’ Photographs of H&E staining, and (e, e’) quantitative analysis of the metastatic nodules from B16F10 and 4T1 metastatic lung tumor-bearing mice, respectively. f, f’ TUNEL, H&E, and Ki67 staining images for tumors. g Photoacoustic images of oxygenated hemoglobin (HBO₂) and hemoglobin (HB), and (h) melanin signals in tumor sites in mice after intratumoral injection with GOx or PCP-Mn-DTA@GOx@1-MT for various time intervals, with images representative of 4 experiments. Scale bar: 100 µm for d, d’, f and f’. Data represent mean ± SD (n = 6 biologically independent samples). P-values were determined by unpaired Student’s t-test (two-tailed), **p < 0.01.