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. 2022 May 16;5:467. doi: 10.1038/s42003-022-03405-w

Fig. 5. TrxR2-Tg liver isolated mitochondria display increased function through direct regulation of the tricarboxylic acid cycle and the electron transport chain (ETC).

Fig. 5

a–d Individual kinetic activities for Complex I (Cx I), complex II (Cx II), complex IV (Cx IV), and complex V-ATP Synthase (Cx V) respectively in TrxR2-Tg mitochondria compared to controls. e Schematics of the tricarboxylic acid cycle (TCA) indicating with dashed lines the section referred. f Citrate synthase activity kinetics was evaluated (n = 4). g The specific function of the TCA cycle enzymes MDH2 and IDH2 were increased in TrxR2-Tg mitochondria relative to non-transgenic controls, evaluated by MDH2 and IDH2 activity assays. (n = 3, assays run in triplicates). Values are Mean ± SEM. *p < 0.05, **p < 0.01.