Table 2.

Variables contributing strongly to OPLS-DA model discriminating between PHZ and SNX

Variable	❙p(corr)❙	VIP
Lactate	− 0.77687	1.82257
IL-13	− 0.70948	1.66652
IL-8	− 0.6973	1.63755
Glutamate	− 0.68288	1.61133
TNF-α	− 0.66947	1.57238
IL-2	− 0.66011	1.55044
LPR	− 0.65954	1.52502
VEGF-A	− 0.63103	1.48236
IL-4	− 0.58531	1.37511
IL-1β	− 0.55034	1.29242
IL-6	− 0.54935	1.29079
IFN-γ	− 0.50683	1.19044
Pyruvate	− 0.46304	1.07022

VIP > 1 and absolute p(corr) > 0.4 are used to determine which variables are most important for the model, [43] meaning these variables contribute most to model group separation

IFN= interferon, IL= interleukin, LPR= lactate-pyruvate ratio, OPLS-DA= orthogonal projection to latent structures discriminant analysis, PHZ= perihemorrhagic zone, SNX= seemingly normal cortex, TNF= tumor necrosis factor, VEGF-A= vascular endothelial growth factor A, VIP= variable influence on projection