Skip to main content
. 2022 Jan 31;36(3):1027–1043. doi: 10.1007/s12028-021-01423-w

Table 1.

Study characteristics

Study Study design/study settings Population Principle diagnosis/additional data Ventilation status Type of PaO2 Hyperoxemia/controls, PaO2 (mm Hg) Outcome measures/timing Scores for poor outcome
Alali [15] CR/multicenter 417 TBI Probably ventilated Average  > 350a/ < 350a GOSE/6 months 1–4b
Bolduc [57] CR/single-center 265 Cardiac arrest/TTM Unassessable N/A  ≥ 300/N/A CPC/N/A 3–5
Brenner [58] CR/single-center 1547 TBI Unassessable Average  > 200/100–200 GCS/Discharge 3–8
Chang [17] CR/single-center 291 Cardiac arrest/ECMO Definitely ventilated First  ≥ 300/60–300 CPC/Discharge 3–5
Ebner [59] CR/multicenter 869 Cardiac arrest/OHCA, TTM Probably ventilated Highest  > 300/60–300 CPC/6 months 3–5
Elmer [60] CR/single-center 184 Cardiac arrest Definitely ventilated At specific time N/A/N/A CPC/Discharge N/A
Fujita [61] CR/multicenter 129 TBI/TTM Probably ventilated First N/A/N/A GOS/6 months 1–3
Fukuda [46] CR/single-center 197 SAH Ventilated and nonventilated Average  ≥ 250a/ < 250a GOS/Discharge 1–3
Gaieski [62] CR/multicenter 111 Cardiac arrest/TTM Probably ventilated N/A  > 300/N/A N/A/N/A N/A
Humaloja [16] CR/single-center 1110 Cardiac arrest Unassessable First  > 300a /60–120a CPC/1 year 3–5
Janz [28] CR/single-center 170 Cardiac arrest/TTM Probably ventilated Highest 310–608a/ ≤ 310a CPC/Discharge 3–5
Jeon [63] CR/single-center 202 SAH Definitely ventilated Average  ≥ 173/ < 173a mRS/3 months 4–6
Johnson [64] CR/multicenter 544 Cardiac arrest Unassessable At specific time  > 300/60–300 CPC/Discharge 3–5
Kiguchi [39] CR/multicenter 662 Cardiac arrest/OHCA Unassessable First  ≥ 300/ < 300 CPC/1 months 3–5
Kupiec [65] CR/single-center 93 post-CPB Definitely ventilated Highest  ≥ 200/120–200 POD/3 d  + 
Lång [47] CR/multicenter 432 SAH Definitely ventilated Average  > 150/97.5–150 GOS/3 months 1–3
Lee [66] CR/single-center 213 Cardiac arrest/TTM Probably ventilated Average  ≥ 156.7a/116.9–134.9a CPC/Discharge 3–5
Li [67] CR/single-center 244 SAH Unassessable Highest  > 200/ ≤ 200 GOS/3 months 1–3
Lopez [68] CP/single-center 333 Ischemic stroke/IAMT Definitely ventilated Highest  > 120/ ≤ 120 mRS/3 months 4–6
Oh [69] CR/multicenter 792 Cardiac arrest/IHCA Unassessable At specific time  ≥ 300/60–299 CPC/Discharge 3–5
Peluso [18] CR/single-center 356 Cardiac arrest/TTM Definitely ventilated Highest  > 300/ ≤ 300 CPC/3 months 3–5
Popovic [38] CR/single-center 49 TBI Definitely ventilated First  > 200/100–200 GOS/Discharge 1–3b
Rai [70] CR/single-center 88 Cardiac arrest/TTM Probably ventilated N/A  ≥ 300/60–299 N/A/N/A N/A
Roberts [71] CP/multicenter 280 Cardiac arrest/TTM Definitely ventilated Highest  > 300/ ≤ 300 mRS/Discharge 4–6
Russell [72] CR/single-center 471 Traumatic injuries Definitely ventilated Highest N/A/N/A GCS/Discharge N/A
Sadaka [73] CR/single-center 165 TBI Unassessable First  ≥ 245/60–240 GOS/Discharge 1–3
Sadaka [74] CR/single-center 56 Cardiac arrest/TTM Probably ventilated First  ≥ 250/60–249 CPC/Discharge 3–5
Spindelboeck [75] CR/multicenter 145 Cardiac arrest/OHCA Definitely ventilated First  > 300/61–300 CPC/1 months or discharge 3–5
Vaahersalo [40] CP/multicenter 409 Cardiac arrest/OHCA Definitely ventilated Average 128–237a/ < 128a CPC/12 months 3–5
Wang [76] CR/single-center 550 Cardiac arrest/IHCA Definitely ventilated First  > 300/60–300 CPC/Discharge 3–5
Yokoyama [19] CR/single-center 196 SAH Definitely ventilated Highest  > 300a/60–120 mRS/Discharge 3–6
Youn [77] CR/single-center 187 Cardiac arrest/OHCA, TTM Probably ventilated Area under curve N/A/N/A CPC/6 months 3–5

CA, cardiac arrest, CP, prospective cohort, CPB, cardiopulmonary bypass, CPC, cerebral performance category, CPR, cardiopulmonary resuscitation, CR, retrospective cohort, DCI, delayed cerebral ischemia, ECMO, extracorporeal membrane oxygenation, GCS, Glasgow Coma Scale, GOS, Glasgow Outcome Scale, GOSE, Glasgow Outcome Scale extended, IAMT, intraarterial mechanical thrombectomy, IHCA, in-hospital cardiac arrest, mRS, modified Rankin Scale, N/A, not applicable, OHCA, out-of-hospital cardiac arrest, PaO2, arterial partial pressure of oxygen, POD, postoperative delirium, ROSC, return of spontaneous circulation, SAH, subarachnoid hemorrhage, TBI, traumatic brain injury, TTM, targeted temperature management

aRepresents groups assigned by the reviewers using most extreme value for PaO2 and the largest number of participants for neurological outcome

bRepresents groups assigned by the reviewers using commonly used cutoff points