Table 3.
Conventional coagulation parameters, coagulation factor activity and anticoagulant proteins of patients with iTBI stratified by INR (n = 88)
| INR <1.2 (n = 72) | INR ≥1.2 (n = 16) | |
|---|---|---|
| Conventional coagulation parameters, median (IQR) | ||
| Quick (%) (reference range 70–130) | 101.0 (90.0–109.0) | 74.0 (69.3–77.8)*** |
| aPTT (seconds) (reference range 23–36) | 28.1 (25.1–30.5) | 32.0 (30.0–35.2)*** |
| Thrombin time (seconds) (reference range 10–17) | 14.0 (13.0–15.0) | 14.0 (13.3–15.0) |
| Fibrinogen (mg/dL) (reference range 276–471) | 371.0 (315.0–462.0) | 389.0 (299.3–504.5) |
| Antithrombin (%) (reference range 83–128) | 99.5 (89.3–113.0) | 94.0 (84.8–103.3)* |
| Coagulation factors and anticoagulant proteins, median (IQR) | ||
| Factor V (%) (reference range 62–139) | 94.5 (79.3–110.8) | 70.5 (51.3–78.8)*** |
| Factor VIII (%) (reference range 50–150) | 136.5 (111.8–175.5) | 119.0 (100.3–169.8) |
| Factor IX (%) (reference range 65–150) | 113.0 (99.5–128.8) | 100.5 (85.3–122.3) |
| Factor XIII antigen (%) (reference range 75.2–154.8) | 88.0 (75.0–104.0) | 68.0 (61.5–83.0)** |
| Protein C (%) (reference range 70.0–140.0) | 98.0 (86.0–112.0) | 82.5 (69.3–92.0)** |
| Protein S (%) (reference range 63.5–149) | 98.5 (81.8–118.3) | 77.5 (67.2–96.3)** |
| D–dimer (µg/L) (reference range 0–232) | 943.0 (418.0–1,300.5) | 1,301.5 (966.0–6,260.5)* |
| Plasminogen (%) (reference range 80–133) | 89.0 (79.0–97.3) | 76.5 (60.0–83.8)** |
Conventional coagulation parameters, coagulation factors, and anticoagulant proteins of patients with iTBI are represented as median and IQR
aPTT activated partial thromboplastin time, INR international normalized ratio, IQR interquartile range, iTBI isolated traumatic brain injury
*P < 0.05, **P < 0.001, ***P < 0.0001: statistically significant differences between patients with iTBI with INR <1.2 and those with INR ≥1.2